The Research

This 14-day, multicenter, randomized, double-blind study investigated the efficacy and safety of a combination nasal spray containing azelastine (an antihistamine) and fluticasone (a corticosteroid) for patients with moderate-to-severe seasonal allergic rhinitis (SAR) during the Texas mountain cedar season. Patients were randomized to receive one of four treatments: azelastine alone, fluticasone alone, azelastine + fluticasone combination, or placebo. The primary outcome was change in total nasal symptom score (TNSS), which included nasal congestion, runny nose, sneezing, and itchy nose.