The Research

📊 Antihistamine

Evidence-based reviews of H1-receptor antagonists in treating allergic rhinitis symptoms including sneezing, itching, and rhinorrhea.

Articles

Antihistamine

Azelastine Nasal Spray: A Look at Its Pharmacology and Clinical Efficacy

S J Golden

J Am Osteopath Assoc • 1999

This review article summarizes the mechanism, clinical efficacy, and safety of azelastine hydrochloride nasal spray in the treatment of seasonal and perennial allergic rhinitis. Azelastine, a second-generation intranasal antihistamine, works not only through H1-receptor antagonism but also by inhibiting inflammatory mediators like leukotrienes, free radicals, and cytokines.