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Our Treatments Are
Grounded in Science

References and Sources



Meta-Analysis: Combination Therapy vs. Monotherapy

Intranasal antihistamine and corticosteroid to treat allergic rhinitis: A systematic review and meta-analysis 


Combined medical therapy in the treatment of allergic rhinitis: Systematic review and meta-analyses

Modified Intranasal Decongestant 

The effect of topical decongestant on blood flow in normal and infected nasal mucosa.

Evaluation of the dose-response relationship for intra-nasal oxymetazoline hydrochloride in normal adults.

The nasal airways response in normal subjects to oxymetazoline spray: randomized double-blind placebo-controlled trial

Combining Intranasal Corticosteroid with Modified Intranasal Decongestant 

Oxymetazoline adds to the effectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis.


Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion.

Impact of Concomitant Administration of Mometasone Furoate and Oxymetazoline Nasal Sprays vs Either Drug Alone or Placebo on Quality of Life in Patients with Seasonal Allergic Rhinitis

Mometasone furoate nasal spray plus oxymetazoline nasal spray: short-term efficacy and safety in seasonal allergic rhinitis

Intranasal Antihistamine

Efficacy and safety of azelastine nasal spray for the treatment of allergic rhinitis

Safety and efficacy of olopatadine hydrochloride nasal spray for the treatment of seasonal allergic rhinitis

Combining Intranasal Corticosteroid with Intranasal Antihistamine

Double-blind, placebo-controlled study of azelastine and fluticasone in a single nasal spray delivery device

Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis

Olopatadine-mometasone combination nasal spray: Evaluation of efficacy and safety in patients with seasonal allergic rhinitis

Intranasal Corticosteroid 

Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications.

Intranasal Anticholinergic 

The anticholinergic agent, ipratropium bromide, is useful in the treatment of rhinorrhea associated with perennial allergic rhinitis

Combining Intranasal Corticosteroid with Intranasal Anticholinergic 

Ipratropium bromide nasal spray 0.03% and beclomethasone nasal spray alone and in combination for the treatment of rhinorrhea in perennial rhinitis

Combining Intranasal Decongestant with Intranasal Anticholinergic 

Efficacy and safety of topical combinations of ipratropium and xylometazoline for the treatment of symptoms of runny nose and nasal congestion associated with acute upper respiratory tract infection

Salinity Spray

Role of nasal saline irrigation in the treatment of allergic rhinitis in children and adults: A systematic analysis

Nasal irrigation as an adjunctive treatment in allergic rhinitis: A systematic review and meta-analysis